NCT02802722

Does Vitamin D Supplementation Enhance Resolution of Inflammation After Community-acquired Pneumonia?

A Prospective Randomised Placebo-controlled Study of the Influence of Vitamin D Supplementation on Resolution of Inflammation Following Community-acquired Pneumonia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: Queen Mary University of London · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

Previous research has shown that people who have been hospitalised for pneumonia are more likely to die of conditions such as heart attacks, stroke and cancer in the weeks to months after their illness. This risk is linked to raised levels of inflammation. Laboratory research shows that vitamin D can help to clear inflammation. Vitamin D deficiency is very common in the United Kingdom. The investigators are conducting this study to find out if taking vitamin D can hasten long-term recovery from pneumonia by reducing inflammation.

Conditions

• Pneumonia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D3 supplementation	Capsules to be dispensed using an electronic dispenser to allow real time logging of adherence.
BIOLOGICAL	Peripheral blood and induced sputum sampling	To attain samples for immunological testing
RADIATION	Chest computerised tomography (CT) scans	For volumetric quantification of lung abnormalities
OTHER	Symptom questionnaire	Symptom questionnaire for recent symptom history
OTHER	Placebo	To be dispensed using an electronic dispenser to allow real time logging of adherence.

Timeline

• Start date: 2017-02-24
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2016-06-16
• Last updated: 2024-04-19

Locations

1 site across 1 country: United Kingdom