NCT02801552

Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF

Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using Platelet-rich Fibrin : A Pilot Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Fujian Medical University · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the clinical effect of regenerative endodontic procedure using PRF in immature permanent teeth with apical periodontitis. Half of participants will receive the PRF instead of blood clots in the regenerative endodontic procedure, while the other half will receive a blood clots in the regenerative endodontic procedure.

Detailed description

The conventional method of regenerative endodontic procedure using a blood clot as scaffold materials has shown successful results. However, it is very difficult to induce bleeding and place mineral trioxide aggregate over a blood clot. Platelet-rich fibrin (PRF), a second-generation platelet concentrate. PRF is a matrix of autologous fibrin containing a large quantity of platelets, growth factors and leukocytes. PRF preparation technique is very simple, inexpensive and doesn't require any chemical agents. The purpose of this study is to test the hypothesis that the use of PRF in regenerative endodontic procedure of immature permanent teeth with apical periodontitis will accelerate periapical bone healing and stimulate the root maturation.

Conditions

• Periapical Periodontitis
• Tooth Diseases
• Stomatognathic Diseases

Interventions

Type	Name	Description
DEVICE	PRF	Regenerative Endodontic Procedure with PRF: autologous PRF will be used instead of blood clot in the second vist.

Timeline

• Start date: 2016-05-01
• Primary completion: 2019-11-01
• Completion: 2020-02-01
• First posted: 2016-06-16
• Last updated: 2021-09-05

Locations

1 site across 1 country: China