NCT02801409

Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer Surgery

Effects of Epidural Anesthesia-analgesia on Long-term Survival in Patients After Lung Cancer Surgery: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (actual)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Available studies suggest that regional anesthesia-analgesia may decrease the occurrence of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking. The purpose of this randomized controlled trial is to investigate the effect of epidural anesthesia-analgesia on recurrence-free survival in patients undergoing lung cancer surgery.

Detailed description

Lung cancer is increasing and is the leading cause of cancer death. Surgical resection is the mainstay of treatment for early stage non-small cell lung cancer. However, long-term survival after lung cancer surgery is far from optimal, and cancer recurrence or metastasis is the main reason leading to cancer death in these patients. The development of cancer recurrence/metastasis largely depends on the balance between tumor-promoting factors and immune function of the body. Studies showed that surgical manipulation releases cancer cells into circulation; and stress response induced by surgery inhibits the cell-mediated immunity. In addition, volatile anesthetics and opioids may also aggravate immunosuppression and potentially worsen long-term outcome. On the other hand, regional anesthesia can blunt surgical stress and reduce anesthetic consumption. These effects may help to preserve immune function and reduce recurrence/metastasis. However, existing evidences are insufficient to draw conclusion in this topic. The purpose of this randomized controlled trial is to test the hypothesize that regional anesthesia-analgesia may reduce recurrence/metastasis and improve long-term survival in patients after lung cancer surgery.

Conditions

• Lung Cancer
• Thoracic Surgery
• Anesthesia, Epidural
• Neoplasm Recurrence, Local
• Neoplasm Metastasis

Interventions

Type	Name	Description
DRUG	General anesthesia alone	General anesthesia is performed during surgery; patient-controlled intravenous analgesia is provided after surgery.
DRUG	Combined epidural-general anesthesia	Combined epidural-general anesthesia is performed during surgery; patient-controlled epidural analgesia is provided after surgery.

Timeline

• Start date: 2015-05-25
• Primary completion: 2017-11-11
• Completion: 2019-11-30
• First posted: 2016-06-15
• Last updated: 2020-08-27

Locations

1 site across 1 country: China