NCT02799290

Adipose Tissue Extract and Platelet-rich Plasma Use for Wound Healing

The Effect of Adipose Tissue Extract and Platelet-rich Plasma on Split-thickness Donor Site Wound Healing. A Comparative Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Tampere University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Adipose Tissue Extract (ATE) has been found to be an autologous source of growth factors with proven in vitro angiogenic and adipogenic properties.It is obtained by a simple lipoaspirate procedure. We sought to compare the effect of ATE with another known source, platelet-rich plasma to compare the wound healing characteristics on skin graft donor sites.

Detailed description

The investigators enrolled 24 participants with an indication for skin graft. Two or more split-thickness grafts are harvested per patient, one serving as control and the other as experimental. The experimental sites were covered with either autologous PRP gel or ATE prepared in the OR, which was selected in an unblinded manner due to surgical theater convenience. However, donor sites were randomized through a computer generator. Covered with a semiocclusive film, wounds were separated and followed up on days 3,5,7,10,14 for wound healing and 30 and 60 for scar evaluation. Digital photography and specto-photocutometry was employed to know the hemoglobin and melanin content of the wounds, and custom-made software was used to calculate the percentage of wound re-epithelialization.

Conditions

• Wound Healing Disturbance of

Interventions

Type	Name	Description
BIOLOGICAL	ADIPOSE TISSUE EXTRACT	Adipose tissue extract is obtained on site with lipoaspirate adipose tissue prepared though incubation and filtration
BIOLOGICAL	PLATELET-RICH PLASMA GEL	Autologous platelet rich plasma is obtained onsite and activated following commercial kit instructions

Timeline

• Start date: 2015-06-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2016-06-14
• Last updated: 2021-01-07
• Results posted: 2021-01-07

Locations

1 site across 1 country: Finland