Trials / Completed
CompletedNCT02797756
Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 35 (actual)
- Sponsor
- NYU Langone Health · Academic / Other
- Sex
- All
- Age
- 24 Years
- Healthy volunteers
- Not accepted
Summary
Using an active cohort of children in whom Airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway sample obtained during the clinically indicated bronchoscopy for microbiome analysis. A case-control study design will be used to study whether subjects with CC with GER have a distinct lung microbiome and increased inflammation as compared with subjects with CC without GER and to determine whether the microbiome and degree of inflammation is related to the type of GER (acidic versus nonacidic).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Esophago-gastro-duodenoscopy (EGD) with biopsy | |
| PROCEDURE | Esophageal Impedance Monitoring (EIM) |
Timeline
- Start date
- 2014-08-05
- Primary completion
- 2018-12-12
- Completion
- 2018-12-12
- First posted
- 2016-06-13
- Last updated
- 2019-01-29
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02797756. Inclusion in this directory is not an endorsement.