Trials / Completed
CompletedNCT02797093
Impact of ART Adherence on HIV Persistence and Inflammation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 71 (actual)
- Sponsor
- University of Colorado, Denver · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate the relationship between anti-retroviral therapy (ART) adherence with levels of human immunodeficiency virus (HIV) reservoir and residual viremia in suppressed, HIV-infected individuals on chronic ART.
Detailed description
Understanding whether the size and dynamics of the HIV reservoir are associated with adherence, measured by an objective biomarker, could have significant clinical and therapeutic implications for ART and HIV cure. 1. First, this aim will quantify levels of CA-RNA, CA-DNA, and plasma residual viremia in suppressed, HIV infected individuals and correlate them with levels of TFV-DP in DBS as a measure of cumulate drug exposure (adherence). 2. Second, this study will evaluate the changes in the HIV reservoir in relation to changes in ART adherence over time.
Conditions
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2018-10-12
- Completion
- 2018-10-12
- First posted
- 2016-06-13
- Last updated
- 2022-03-08
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02797093. Inclusion in this directory is not an endorsement.