NCT02791074

Heart Failure Ventricular Pressure Time Profile

Non-invasive Determination of Intra-left Ventricular Pressure-time Profile for Diagnosis of Heart Failure With Normal and Reduced Ejection Fraction.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 75 (actual)
• Sponsor: National Heart Centre Singapore · Academic / Other
• Sex: All
• Age: 21 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This proposed study aim to: 1. Determine intra-LV pressure-time profile non-invasively using recently developed echo Doppler VFM analysis and applanation tonometry and myocardial elastic properties, in HF subjects (both HFNEF and HFREF) compared to normal volunteers. 2. Correlate calculated intra-LV pressure parameters with NT ProBNP levels.

Detailed description

Heart failure (HF) is a common disease and its syndrome is difficult to diagnose. HF with reduced ejection fraction (HFREF) may be diagnosed based on impaired LVEF (\<50%). However, diagnosis of HF with normal ejection fraction (HFNEF) is mainly based on the presence of signs and symptoms. Central to diagnosis of HF is estimation of intra-cardiac pressure, which can only be obtained from invasive catheterization. This proposed study aim to: 1. Determine intra-LV pressure-time profile non-invasively using recently developed echo Doppler VFM analysis and applanation tonometry and myocardial elastic properties, in HF subjects (both HFNEF and HFREF) compared to normal volunteers. 2. Correlate calculated intra-LV pressure parameters with NT ProBNP levels.

Conditions

• Heart Failure

Interventions

Type	Name	Description
OTHER	NTproBNP	To assess its level in the blood, as a marker of heart failure presence and severity.
OTHER	Echocardiography	To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
OTHER	Arterial tonometry	A noninvasive method to obtain arterial pressure waveform.

Timeline

• Start date: 2013-05-01
• Primary completion: 2017-02-01
• Completion: 2017-03-01
• First posted: 2016-06-06
• Last updated: 2017-03-31

Locations

1 site across 1 country: Singapore