NCT02791009

Asian neTwork for Translational Research and Cardiovascular Trials ("ATTRaCT")

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 815 (actual)
• Sponsor: National Heart Centre Singapore · Academic / Other
• Sex: All
• Age: 21 Years – 99 Years
• Healthy volunteers: Accepted

Summary

To build on Singapore's competitive advantages in advanced cardiac imaging, genetic and molecular studies to develop an integrated "one -stop" platform spanning from human to large and small animal models, dedicated to deepening the understanding of CV disease progression, discovery of new targets and repurposing of drugs.

Detailed description

Heart failure (HF) is the final common pathway of cardiovascular (CV) diseases and leading cause of CV hospitalizations in Singapore and worldwide, with a mortality rate that rivals most cancers (\>50% mortality at 5 years). Also similar to cancer, HF is a staged disease where early detection and treatment are vital for prevention of disease progression from Stage A (risk factors) to Stage B (subclinical structural heart disease) and Stage C (symptomatic HF). Cardiac imaging is critical for the detection of early subclinical disease. There is limited understanding of the mechanisms underlying disease progression and effective therapies are limited, particularly for the half of the HF population with preserved ejection fraction (HFPEF or "diastolic HF") for which there is no effective therapy to date (in contrast to HF with reduced ejection fraction \[HFREF\] or "systolic HF"). The investigators overall aim is to build on Singapore's competitive advantages in advanced cardiac imaging, genetic and molecular studies to develop an integrated "one -stop" platform spanning from human to large and small animal models, dedicated to deepening the understanding of CV disease progression, discovery of new targets and repurposing of drugs.

Conditions

• Heart Failure

Interventions

Type	Name	Description
OTHER	Cardiovascular Magnetic Resonance Imaging (CMRI)	CMRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create images; for about 1 hour. Several sets of images are needed. No injection of drug or dye will be used for this procedure.
OTHER	Electrocardiogram (ECG)	ECG is a non-invasive test used to detect any underlying heart conditions by measuring the electrical activity of the heart.
OTHER	Blood Sample Collection	Blood will be drawn for circulating biomarkers, which are measurable indicators of the severity or presence of the heart failure condition.
OTHER	Clinical Assessment	Check health status, blood pressure, heart rate, height and weight measured. In addition, subject will undergo a heart examination.
OTHER	Cardiovascular Ultrasound (CVUS)	To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help the investigators understand the type and severity of heart failure.
OTHER	Cognitive Test	To relate the presence and severity of cognitive impairment (CI) with simultaneously acquired advanced cardiovascular imaging characteristics and circulating biomarkers of cardiovascular function, inflammation and coagulation.

Timeline

• Start date: 2015-08-01
• Primary completion: 2021-03-31
• Completion: 2021-03-31
• First posted: 2016-06-06
• Last updated: 2024-04-05

Locations

1 site across 1 country: Singapore