NCT02790203

Perioperative Use of a Selective COX2 Inhibitor in Patients Undergoing Elective Colorectal Surgery: the Effect on Post-operative Bowel Motility and Post-operative Pain

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Perioperative Celecoxib to promote bowel movement and to reduce post-operative pain after elective colonic resection.

Detailed description

Post-operative ileus is a common surgical complication occurring in with up to 20% of patients, with a significant clinical and economical effect. Many preventative measures have been tested to promote gastrointestinal motility following intestinal surgery have been suggested. The medical intervention in the proposed study includes administration of a selective COX-2 inhibitor, specifically Celecoxib, in the peri-operative period following an elective colon resection. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic therapeutic effects. The drug is approved for use in by the ministry of health in Israel and in the United states. The study aims to assess the use of this widely used medication for evaluation of the clinical effect on post-operative bowel transit, as well as the drugs' effect on post-operative pain.

Conditions

• Prevention of Post Operative Ileus

Interventions

Type	Name	Description
DRUG	Celecoxib	NSAIDS
DRUG	Placebo	Placebo

Timeline

• Start date: 2016-06-01
• Primary completion: 2018-12-01
• First posted: 2016-06-03
• Last updated: 2016-06-03