NCT02789072

Effects of Microgravity on Central Aortic Pressure During Parabolic Flights

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Cardiovascular events remain the main cause of death of the industrialized world (Global status report on noncommunicable diseases 2010. Geneva, World Health Organization, 2011). Arterial hypertension, hyperlipoproteinemia, smoking, diabetes and family history represent the main cardiovascular risk factors. Arteriosclerosis leads to coronary heart disease, cerebrovascular insufficiency and peripheral vascular diseases that reflect in myocardial infarction and stroke. The main objective of this experiment is to investigate the differential effect of microgravity on central aortic blood pressure. The main criterion is the central aortic pressure (measured in mmHg). The hypothesis is that microgravity leads to an increased central aortic pressure.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	central aortic pressure (measured in mmHg).	Blood pressure will only be measured during the 0g (microgravity) phase. Seven 5 ml blood sample will be drawn in the aircraft: before the first parabola (1) and after each block of 5 parabola (6). On ground after flight, a 9th 5 ml blood sample will be drawn and then the mobil-o-graph, the SOMNOtouch NIBP and the intravenous cannula will be removed.

Timeline

• Start date: 2015-09-01
• Primary completion: 2018-09-01
• Completion: 2018-09-01
• First posted: 2016-06-02
• Last updated: 2016-06-02

Locations

1 site across 1 country: France