NCT02787954

Prospective Tumor Response Evaluation

Prospective Evaluation of Tumor Response to Cancer Treatment Therapies

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 10 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if MRI imaging can detect genetic, proteomic, and metabolomic characteristics of liver tumors. The study also aims to determine if these imaging characteristics are correlated with clinical outcomes.

Detailed description

For each treatment arm, pre-procedural MRI and post procedural MRI will be obtained. Pre-procedural biopsies will be obtained, if possible. Pretreatment genetic expression, proteomic, or metabolomic patterns from the tumor samples will be assessed. Imaging characteristics from tumors will be extracted using automated software-the study will apply a computational analysis system with the capability to extract and analyze imaging characteristics and correlate them to genetic expression, proteomic, and metabolomic tumor characteristics. Imaging findings will be correlated to clinical outcomes and genetic, proteomic, and metabolomic findings to determine association. Imaging findings and genomic, proteomic, and metabolomic tumor characteristics will be correlated to clinical outcomes (time to recurrence, overall survival, 3-month, 6-month, and 1-year survival).

Conditions

• Hepatocellular Cancer
• Metastatic Liver Cancer

Interventions

Type	Name	Description
PROCEDURE	TACE	Procedure for giving chemotherapy directly to tumor cells.
PROCEDURE	Y-90	Using a combination of radiation and chemotherapy directly on the tumor cells to cause cell death.
PROCEDURE	MWA	Using heat to kill tumor cells.
PROCEDURE	IRE	Using energy to disrupt tumor cell activity, thereby causing cellular death.

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2016-06-01
• Last updated: 2018-10-18

Locations

1 site across 1 country: United States