NCT02785809

Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception

Recovery of Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception: Is the Recovery Period Related to AMH?

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Anders Nyboe Andersen · Academic / Other
• Sex: Female
• Age: 26 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate whether there is a correlation between anti-Müllerian hormone during long-term use of combined oral contraceptives and the recovery time before recovered menstrual cycle after discontinuation of oral contraceptives.

Detailed description

Background: Hormonal contraception is widely used among women worldwide; 50-89% of all women in the Western countries use oral contraception at some point in their lives. Oral contraceptives (OC) suppress the hypothalamic-pituitary-ovarian axis through a negative feedback of ethinyl estradiol and progestins and thereby potentially influence the markers of ovarian reserve due to a suppressed release of gonadotropins, which will impair the growth of antral follicles. Methods and Materials: Participants for this studies will be included through the Fertility Assessment and Counseling Clinic, Rigshospitalet, Herlev- and Hvidovre Hospital. Inclusion criteria: Use of oral contraception (for study 3 at least during the last three years). Exclusion criteria: Known infertility, known thyroid disease. Aims: Study 3: Investigate the ovarian reserve markers after discontinuation of OC over a period of three months in women with a history of long-term OC use. The women will be followed with serial ultrasounds and blood samples and will complete a menstrual calendar.

Conditions

• Oral Contraceptives
• Long-term Use
• AMH
• Ovarian Reserve Parameters

Interventions

Type	Name	Description
OTHER	Pausing oral contraceptive

Timeline

• Start date: 2016-04-01
• Primary completion: 2019-05-01
• Completion: 2020-03-01
• First posted: 2016-05-30
• Last updated: 2016-05-30

Locations

1 site across 1 country: Denmark