NCT02785653

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium Under Routine Clinical Practice

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Maharashtra University of Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the potentiation of muscle relaxation caused by rocuronium by inhalational agent sevoflurane. Half the patients will be ventilated with oxygen ,nitrous oxide and sevoflurane during induction of anaesthesia and half will be ventilated only with oxygen and nitrous oxide.

Detailed description

Rocuronium is a non depolarizing muscle relaxant. Inhalational general anaesthetic agents like Sevoflurane have some muscle relaxation effect by depressing the spinal motor neurons. Inhalational anaesthetics also alter the tonic input received from descending modulatory systems from the brain. Deep anaesthesia with inhalational agents may cause some degree of neuromuscular blockade.

Conditions

• Muscle Relaxation Caused by Sevoflurane

Interventions

Type	Name	Description
DRUG	Sevoflurane	Patients were ventilated with 2 % inspired concentration of sevoflurane in a fresh gas flow of 5 litres containing 66.6% nitrous oxide and 33.3% percent of oxygen
DRUG	Rocuronium	rocuronium 0.6mg per kg body weight was given intravenously after induction of anaesthesia

Timeline

• Start date: 2004-04-01
• Primary completion: 2006-11-01
• Completion: 2006-11-01
• First posted: 2016-05-30
• Last updated: 2016-06-09

Locations

1 site across 1 country: India