NCT02784860

Effects of Intravenous Lidocaine During Sedation for Colonoscopy.

Investigation of the Effects of Intravenous Lidocaine Infusion During Sedation for Colonoscopy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Liege · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the gastroenterologist. Patients will be randomly allocated into two groups: lidocaine infusion (bolus of 1.5 mg/kg followed by a continuous infusion of 4 mg/kg/h) or the same volume of placebo (normal saline)

Detailed description

The potential benefits of lidocaine infusion will be tested on: * propofol consumption (primary outcome) * intraoperative respiratory depression * time for patient recovery * postoperative fatigue * postoperative pain * postoperative cognitive dysfunction

Conditions

• Colonoscopy

Interventions

Type	Name	Description
DRUG	Lidocaine	Propofol (0.5 mg/kg or more) is titrated to provide loss of consciousness. Then in the lidocaine group, lidocaine 2% is administered as a bolus followed by a continuous intravenous infusion after loss of consciousness
DRUG	normal saline	Propofol (0.5 mg/kg or more) is titrated to provide loss of consciousness. Then in the placebo group, the same volume of normal saline is administered after loss of consciousness

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-09-01
• Completion: 2016-10-01
• First posted: 2016-05-27
• Last updated: 2018-01-03

Locations

1 site across 1 country: Belgium