NCT02783859

Hospitalised Pneumonia With Extended Treatment (HOPE) Study

A Multi-centre Double-blind Randomised Controlled Trial to Determine if a Longer Duration of Amoxicillin-clavulanic Acid (Compared to Shorter Duration) Improves Clinical Outcomes of Children Hospitalised With Community-acquired Pneumonia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 314 (actual)
• Sponsor: Menzies School of Health Research · Academic / Other
• Sex: All
• Age: 3 Months – 5 Years
• Healthy volunteers: Not accepted

Summary

An intervention study to determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia

Detailed description

A multi-centre double-blind randomised controlled trial to determine if a longer duration of amoxicillin-clavulanic acid (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised with community-acquired pneumonia, in Indigenous children and a developing country

Conditions

• Pneumonia

Interventions

Type	Name	Description
DRUG	Amoxicillin-clavulanic Acid
DRUG	Placebo (for Amoxicillin-clavulanic Acid)

Timeline

• Start date: 2016-06-01
• Primary completion: 2022-06-01
• Completion: 2022-12-01
• First posted: 2016-05-26
• Last updated: 2026-01-15

Locations

5 sites across 3 countries: Australia, Malaysia, New Zealand