NCT02782221

Lipolytic Effects of GH in Human Subjects in Vivo

Lipolytic Effects of GH in Human Subjects in Vivo: Molecular Mechanisms and Temporal Patterns

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Growth hormone (GH) induces fat metabolism. The mechanisms underlying the fat metabolizing effects of GH remain elusive. However, it is known that insulin suppresses fat metabolism, and GH inhibits the expression of certain insulin-dependent signaling proteins. We therefore hypothesize that the fat metabolizing effects of GH depend on abrogation of insulin-dependent signaling pathways. In order to investigate the fat metabolizing effects of GH, we'll analyze consecutive adipose tissue biopsies taken after GH exposure and GH blocking, respectively. Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.

Conditions

• Metabolic Diseases
• Growth Hormone Treatment

Interventions

Type	Name	Description
DRUG	Growth Hormone	Subjects are receiving one injection of growth hormone (Genotropin) 0,5 mg
DRUG	Pegisomant	One the placebo day the subjects are receiving injection with pegvisomant (Somavert 30 mg) to block the action of endogenous growth hormone

Timeline

• Start date: 2016-05-30
• Primary completion: 2016-09-22
• Completion: 2017-01-15
• First posted: 2016-05-25
• Last updated: 2020-03-26

Locations

1 site across 1 country: Denmark