NCT02781493

Efficacy of Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopy

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Prucalopride based bowel cleansing regimen might be helpful to improve bowel cleansing quality before colonoscopy.

Detailed description

Colonoscopy is the standard approach for evaluating the colon currently. Thorough bowel cleansing is critical for adequate visualization of colonic mucosa during colonoscopy. Inadequate bowel cleansing results in adverse consequences for the examination, including lower adenoma detection rates, longer procedural time, lower cecal intubation rates, shorter intervals between examinations and an estimated 12-22% increase in overall colonoscopy cost.Unfortunately, despite advances in bowel preparation methods, up to one-third of all colonoscopies are reported to have an inadequate bowel preparation. Prucalopride can accelerate colonic transit and has been demonstrated to be efficient in constipation.

Conditions

• Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopyp

Interventions

Type	Name	Description
DRUG	2 mg Prucalopride plus 2 L Polyethylene Glycol regimen	Patients enrolled in the Prucalopride group will recieve 2 mg Linaclotide plus 2 L Polyethylene Glycol regimen before colonoscopy.
DRUG	2 mg Placebo plus 2 L Polyethylene Glycol regimen	Patients enrolled in the Placebo group will recieve 2 mg Placebo plus 2 L Polyethylene Glycol regimen before colonoscopy.

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-03-01
• Completion: 2017-03-01
• First posted: 2016-05-24
• Last updated: 2016-05-27

Locations

1 site across 1 country: China