NCT02778750

Evaluation Of The Pan-microbiome and Host Immune Response in CF

Evaluation Of The Pan-microbiome and Host Immune Response in Cystic Fibrosis (CF)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 12 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Investigators will examine temporal and regional dynamic changes in the microbiome of Cystic Fibrosis patients to explore microbiome features that are associated with an inflammatory phenotype. Investigators hypothesize that temporal and spatial differences in lung microbiome are associated with host inflammatory responses. While chronic and polymicrobial airway colonization are commonly recognized in cystic fibrosis (CF), it is unclear what factors of the microbial environment lead to infection with pathogenic microorganism. This is a multi center, longitudinal cohort of adult Cystic Fibrosis subjects recruit4ed from NYU and Columbia to understand how changes in the airway microbiome may affect the host inflammatory responses in Cystic Fibrosis (CF). There will be three approaches to understanding inflammatory responses; 1) a longitudinal assessment of temporal changes in the microbiome over a 6-month period of clinical stability; 2) comparison of the regional differences in airway microbiome between lung segments with more versus less disease; 3) evaluation of functional aspects of the lung microbiome.

Conditions

• Cystic Fibrosis (CF)

Interventions

Type	Name	Description
PROCEDURE	Two-Bronchoscope Technique	Used to validate the use of sputum to sample the lower airway microbiome

Timeline

• Start date: 2015-06-05
• Primary completion: 2017-06-16
• Completion: 2020-03-12
• First posted: 2016-05-20
• Last updated: 2023-07-11

Locations

1 site across 1 country: United States