NCT02778243

Sexual Steroids: Relationship Between Serum and Prostatic Tissue Level

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 107 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients followed in the Foch Hospital Urology Department (Suresnes): Patients justifying a prostatectomy. * Patients justifying prostatectomy together with the bladder (radical cystectomy for bladder cancer). * Patients with benign prostate hyperplasia who justified a prostatectomy. Compare serum sexual steroid concentrations and intra-tissue on healthy prostates and prostate adenoma, assess concentrations intra-tissue sex steroids on cancer metastasis prostate specific blood sample under study (30mL) will be performed preoperatively in Patients followed in Foch Hospital Urology Department (Suresnes), and a Removal of a fragment of prostate tissue or metastasis will be analyze. Aim is to compare serum concentrations of sexual steroids and intra-tissue on healthy prostates and prostate adenomas compared to concentrations measured in patients operated for prostate cancer.

Detailed description

Steroids concentration will be determined using Gas chromatography-mass spectrometry. The analyzed steroids are : FSH :Mul/ml LH: mUI/ml SHBG: µg/ml BT: ng/ml TT: ng/ml DHT: ng/ml DHEA: ng/ml D5: ng/ml D4: ng/ml E1: pg/ml E2 : pg/ml DHEA-S : µg/dl

Conditions

• Urinary Bladder Neoplasms
• Prostate Hyperplasia

Interventions

Type	Name	Description
BIOLOGICAL	steroids concentrations determination

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-11-12
• Completion: 2016-11-12
• First posted: 2016-05-19
• Last updated: 2017-06-14

Locations

1 site across 1 country: France