NCT02777619

Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia

Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Target-controlled Infusion Intravenous Anesthesia During the Induction

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Guangzhou General Hospital of Guangzhou Military Command · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).

Detailed description

64 cases were randomly divided into four groups, In each group, dexmedetomidine target plasma concentration are 0, 0.4, 0.6, 0.8 ng/ml. Dexmedetomidine administered 15 min before target controlled infusion of propofol. The propofol infusion was started to provide a target effect-site concentration of 1.0ug/ml, and increased by 0.2ug/ml until loss of consciousness when the effect-site concentration and target concentration equilibrium.

Conditions

• Pharmacodynamic Interaction

Interventions

Type	Name	Description
DRUG	0.0ng/ml Dexmedetomidine	Dexmedetomidine target plasma concentration is 0.0ng/ml
DRUG	0.4ng/ml Dexmedetomidine	Dexmedetomidine target plasma concentration is 0.4ng/ml
DRUG	0.6ng/ml Dexmedetomidine	Dexmedetomidine target plasma concentration is 0.6ng/ml
DRUG	0.8ng/ml Dexmedetomidine	Dexmedetomidine target plasma concentration is 0.8ng/ml
DRUG	Propofol

Timeline

• Start date: 2016-01-01
• Primary completion: 2016-06-01
• Completion: 2016-07-01
• First posted: 2016-05-19
• Last updated: 2016-07-28

Locations

1 site across 1 country: China