NCT02776943

UCMSC Transplantation in the Treatment of Cartilage Damage

Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee and Knee Osteoarthritis

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: South China Research Center for Stem Cell and Regenerative Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.

Detailed description

Human cartilage only has limited regenerative potential. Transplantation of umbilical cord mesenchymal stem cells (UCMSCs) is a promising strategy given the high proliferative capacity of MSCs and their potential to differentiate into cartilage-producing cells - chondrocytes. The acquisition of ucMSCs does not require invasive surgical intervention or cartilage extraction from other sites as required by other cell-based strategies. The investigators inject allogeneic human mesenchymal stem cells to the cartilage lesions in patients via intra-articular injection method, and to investigate the efficacy and safety。

Conditions

• Cartilage Damage
• Degenerative Osteoarthritis

Interventions

Type	Name	Description
BIOLOGICAL	umbilical cord mesenchymal stem cells
DEVICE	Hyaluronic acid

Timeline

• Start date: 2016-06-01
• Primary completion: 2018-12-01
• Completion: 2019-06-01
• First posted: 2016-05-18
• Last updated: 2016-05-18