NCT02775084

Fish Oil T Cell Function

Nutritional Intervention to Test Effect on Healthy Human T Cell Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Texas A&M University · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to examine the effect of dietary n-3 polyunsaturated fatty acid supplementation on subjects' pan CD4+ T cell function, cognition, and muscle function. Half of the participants will receive fish oil, while the other half will receive a placebo (olive oil).

Detailed description

Generalized inflammation has been consistently associated with aging and metabolic diseases, often characterized by reduced muscle and cognitive function. Although much of the aging-associated inflammation has been attributed to chronic activation of the innate host defense system, activated CD4+ T cells have been shown to contribute directly to the pathogenesis of several other inflammatory diseases. In humans, dietary n-3 polyunsaturated fatty acids (PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have anti-inflammatory properties and reduce disease symptoms, in part, through suppression of CD4+ T cell activation. Therefore, the Researchers' overall hypothesis is that dietary supplementation with DHA and EPA in humans will ameliorate inflammatory symptoms, in part, by suppressing CD4+ T cell activation, positively affecting muscle and cognitive function.

Conditions

• Muscle Strength
• Cognitive Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fish Oil	4 capsules twice daily with food for 6 weeks
DIETARY_SUPPLEMENT	Olive Oil	4 capsules twice daily with food for 6 weeks

Timeline

• Start date: 2016-01-01
• Primary completion: 2016-06-01
• Completion: 2019-04-01
• First posted: 2016-05-17
• Last updated: 2019-04-22

Locations

1 site across 1 country: United States