NCT02772939

Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation

Evaluation of Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Heart Center Leipzig - University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This trial is designed to establish invasive and non-invasive measures of arterial stiffness as potential predictors of treatment response to renal sympathetic denervation

Detailed description

Regardless of the ongoing debate on the general effect of renal sympathetic denervation in therapy resistant hypertension, all trials published so far face the problem of a certain proportion of nonresponders to treatment. Previous data shows, that to some extent this might be attributable to arterial stiffening. Elevated invasive pulse wave velocity as an established marker for arterial stiffness has been found to be associated with nonresponse to renal denervation treatment in a smaller trial population. This trial attempts to assess the predictive value of different invasive and non-invasive markers for arterial stiffness in an adequately powered population.

Conditions

• Therapy Resistant Arterial Hypertension

Interventions

Type	Name	Description
DEVICE	Renal sympathetic denervation (RDN)	Catheter based renal sympathetic denervation for therapy resistant arterial hypertension

Timeline

• Start date: 2015-06-01
• Primary completion: 2020-09-01
• Completion: 2022-05-01
• First posted: 2016-05-16
• Last updated: 2022-08-10

Locations

1 site across 1 country: Germany