Trials / Completed
CompletedNCT02769299
Cardiotoxicity of Radiation Therapy (CTRT)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 147 (actual)
- Sponsor
- Abramson Cancer Center at Penn Medicine · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The overall objective of this proposal is to determine the utility of sensitive imaging and biomarker measures in detecting subclinical cardiotoxicity across a spectrum of radiation doses to the heart. We will focus specifically on patients receiving photon or proton chest radiotherapy. Our broad working hypothesis is that RT induces early, subclinical CV injury, as evidenced by cardiomyocyte inflammation and necrosis, and worsening CV function.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | Radiation Therapy | less than 1 Gy with protons to 4-8 Gy with photons |
Timeline
- Start date
- 2015-06-02
- Primary completion
- 2018-11-26
- Completion
- 2018-11-26
- First posted
- 2016-05-11
- Last updated
- 2019-01-09
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02769299. Inclusion in this directory is not an endorsement.