NCT02768168

The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: General Hospital of Ningxia Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the efficacy of dezocine pretreatment on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).

Detailed description

Dexamethasone is a synthetic glucocorticoid, which may cause perineal irritation when given intravenously. The major clinical manifestations are pruritus and pain，and the incidence vary between 38%-71%. Some patients undergo spontaneous remission, while others develop into severe pain or pruritus. Dezocine, a new synthetic opiate agonist-antagonist, has been used for the treatment of pain and pruritus, but its role in relieving dexamethasone induced perineal irritation has not been studied yet. The aim of this study was to investigate the efficacy of dezocine pretreatment on dexamethasone induced perineal irritation.

Conditions

• Adverse Effect

Interventions

Type	Name	Description
DRUG	dezocine	receive dezocine 0.1 mg/kg
OTHER	normal saline	receive matching placebo (equal volume of normal saline)

Timeline

• Start date: 2016-05-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2016-05-11
• Last updated: 2016-08-03

Locations

1 site across 1 country: China