NCT02764749

Cranberry (Poly)Phenol Consumption on Vascular Function

Sustained Effects of Cranberry (Poly)Phenol Consumption on Vascular Function in Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Epidemiological studies suggest that the consumption of (poly)phenols rich foods such as cocoa, tea, fruits and vegetables is associated with lower blood pressure, reduced cholesterol and decreased cardiovascular risk. Cranberries are a rich source of (poly)phenols, including anthocyanins, proanthocyanidins and phenolic acids. Whether cranberries can improve vascular function when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of cranberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk. This study also aims to reveal which cranberry (poly)phenols have bioactive properties in healthy men. Consequently, plasma and urine metabolite peaks will be correlated with vascular outcomes and genome-wide expression microarrays will be performed to reveal cell signaling pathways associated with cranberry (poly)phenol-mediated cardioprotective events.

Conditions

• Healthy Young

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	cranberry (poly)phenol containing supplement	Sustained intake of 9 grams of freeze-dried cranberry powder per day (2x 4.5 grams daily over 1 month). The powder is dissolved in water and administered as a drink.
DIETARY_SUPPLEMENT	Placebo comparator: cranberry (poly)phenol deprived supplement	Sustained intake (2x 4.5 grams daily over 1 month) of a control supplement dissolved in water

Timeline

• Start date: 2016-06-01
• Primary completion: 2016-10-01
• Completion: 2016-10-01
• First posted: 2016-05-06
• Last updated: 2016-11-28

Locations

1 site across 1 country: Germany