NCT02764307

Aerosol Delivery in Different Types of Nebulizers

Evaluation of Aerosol Delivery in Different Types of Nebulizers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Chang Gung University · Academic / Other
• Sex: All
• Age: 20 Years – 25 Years
• Healthy volunteers: Accepted

Summary

Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults. Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.

Detailed description

Material and Methods The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers: 1. a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan); 2. a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany); 3. a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and 4. a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.

Conditions

• Asthma

Interventions

Type	Name	Description
DEVICE	Constant jet nebulizer	A constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
DEVICE	Breath enhanced nebulizer	A breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
DEVICE	Manual-actuated nebulizer	A manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
DEVICE	Breath-actuated nebulizer	A breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.

Timeline

• Start date: 2015-10-01
• Primary completion: 2016-10-01
• Completion: 2016-12-01
• First posted: 2016-05-06
• Last updated: 2017-02-01