NCT02760121

AZ, MZ, and the Pulmonary System Response to Hypoxia

The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Hypoxia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this proposal is to compare the physiological effects of acetazolamide (AZ) and methazolamide (MZ) on the control of breathing and hypoxic pulmonary vasoconstriction. The first objective is to assess the effects of AZ and MZ on the control of breathing in normoxia and hypoxia. To achieve this the ventilatory interaction between oxygen and carbon dioxide will be measured and effects compared between placebo, AZ, and MZ conditions. In addition, the isocapnic and poikilocapnic hypoxic ventilatory response and hypercapnic ventilatory response will be measured with each drug. The second objective is to assess the effects of AZ and MZ on the control of the pulmonary vasculature during hypoxia. Pulmonary pressure and cardiac output will be measured during 60 minutes of poikilocapnic hypoxia.

Conditions

• Altitude Sickness
• Hypertension, Pulmonary

Interventions

Type	Name	Description
DRUG	Acetazolamide
DRUG	Methazolamide
DRUG	Placebo

Timeline

• Start date: 2016-05-01
• Primary completion: 2016-08-01
• Completion: 2016-08-01
• First posted: 2016-05-03
• Last updated: 2016-10-19

Locations

1 site across 1 country: Canada