NCT02759965

Neuroinflammation and Cognitive Dysfunction After Orthopedic Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: Karolinska University Hospital · Academic / Other
• Sex: Male
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The primary hypothesis that orthopaedic surgery induces a neuroinflammatory response within 48 hours after elective hip or knee surgery and that there is an association between exaggerated CNS inflammatory response or impaired inflammatory resolution and postoperative cognitive dysfunction within one week and at three months postoperatively.

Detailed description

Patients at 50-85 years of age undergoing orthopedic surgery will be investigated in the perioperative period to detect signs of neuroinflammation using serial CSF and blood sampling for 48 hours in combination with cognitive testing preoperatively, at 3-7 days and after 3 months.

Conditions

• Surgery
• Acute Phase Reaction

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-03-30
• Completion: 2018-12-31
• First posted: 2016-05-03
• Last updated: 2019-04-16

Locations

2 sites across 1 country: Sweden