NCT02756715

The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Detailed description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order. 1. Preoperation (immediate before anesthesia induction) 2. Immediate before tourniquet off 3. 5 min after tourniquet off 4. PACU 5. postoperative 6 hours 6. postoperative 24 hours Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Conditions

• Ischemia

Interventions

Type	Name	Description
DRUG	propofol group	Patient will be anesthetized by using propofol infusion during operation.
DRUG	Desflurane group	Patient will be anesthetized by using desflurane inhalation during operation.

Timeline

• Start date: 2016-05-30
• Primary completion: 2018-03-26
• Completion: 2020-02-27
• First posted: 2016-04-29
• Last updated: 2020-02-28

Locations

1 site across 1 country: South Korea