NCT02750397

HIV-to-HIV Transplant at MGH

Prospective Study of HIV+ Deceased Donor Transplant for HIV+ Recipients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice. HIV+ individuals who receive a solid organ transplant from HIV-uninfected donors will also be followed.

Detailed description

This is an observational study designed to evaluate safety and outcomes of solid organ transplantation in HIV+ recipients of HIV+ deceased donors. This study will evaluate overall survival and graft survival compared to transplantation with an HIV- organ. In addition the study will assess potential complications of organ transplant using HIV+ deceased donors - including but not limited to - HIV superinfection, incidence and severity of graft rejection, recurrence of HIV-associated nephropathy, incidence of bacterial infections, and opportunistic infections.

Conditions

• HIV
• Awaiting Organ Transplant

Timeline

• Start date: 2016-08-01
• Primary completion: 2025-07-15
• Completion: 2025-07-16
• First posted: 2016-04-25
• Last updated: 2025-09-25

Locations

1 site across 1 country: United States