Trials / Active Not Recruiting
Active Not RecruitingNCT02750319
Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery
A Randomized, Double-Blind, Controlled Trial of Combined Amiodarone and N-Acetylcysteine Versus Amiodarone Plus Placebo for the Prevention of Atrial Fibrillation in High Risk Patients Undergoing Thoracic Surgery
- Status
- Active Not Recruiting
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 184 (actual)
- Sponsor
- Memorial Sloan Kettering Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This trial will be comparing the combination of amiodarone and NAC (n=122) to amiodarone alone and NAC matched placebo (n=122) to determine the rates with which sustained (lasting \>30 seconds) or clinically significant POAF is reduced in high risk patients within 7 days after major thoracic surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Amiodarone | |
| DRUG | N-Acetylcysteine | |
| DRUG | Placebo |
Timeline
- Start date
- 2016-04-01
- Primary completion
- 2026-04-01
- Completion
- 2026-04-01
- First posted
- 2016-04-25
- Last updated
- 2025-05-16
Locations
9 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT02750319. Inclusion in this directory is not an endorsement.