NCT02747277

Analysis of B Cells From Autoimmune Individuals

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 46 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells of individuals genetically susceptible to autoimmunity display defects in the biological process of tolerance, which removes B cells that participate in autoimmunity.

Detailed description

Peripheral blood B cells of SLE patients are analyzed by flow cytometry to determine the frequency of B cells co-expressing immunoglobulin kappa an lambda light chains. This frequency is correlated to the disease activity.

Conditions

• Lupus Erythematosus
• Rheumatoid Arthritis
• Type 1 Diabetes

Timeline

• Start date: 2016-05-01
• Primary completion: 2022-01-01
• Completion: 2022-01-01
• First posted: 2016-04-21
• Last updated: 2023-12-04

Locations

1 site across 1 country: United States