NCT02745730

RS-fMRI to Nutrient Shakes

Resting State Functional Magnetic Resonance Imaging of Human Brain Responses to Nutrient Shake

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Unilever R&D · Industry
• Sex: Male
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

Resting state functional magnetic resonance imaging (rsfMRl) of the brain is used to measure pleasantness after consumption of four different milkshakes with added sugars or sweeteners.

Detailed description

The central role of the brain in regulating food intake and steering feeding behaviour is increasingly recognized. It is currently well accepted that the brain is the target organ to measure the effects of pleasantness and energy homeostasis in order to change feeding behaviour to reduce the rising prevalence of obesity. The effects of food on the brain are multiple and complex. In addition to primary aspects of food such as taste, texture, looks and smell, secondary aspects such as energy regulation are as much important in the entire "eating experience". Resting state functional connectivity in the brain can be assessed by the analysis of low-frequency fluctuations present in the blood-oxygenation-level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). Investigators will use resting state functional magnetic resonance imaging (rsfMRl) to detect changes in connectivity in the default mode and salience network after consumption of four different milkshakes with added sugars or sweeteners.

Conditions

• Pleasure

Interventions

Type	Name	Description
OTHER	Glucose
OTHER	Fructose
OTHER	Sucralose
OTHER	Allulose

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-06-01
• Completion: 2016-10-01
• First posted: 2016-04-20
• Last updated: 2016-11-21

Locations

1 site across 1 country: Netherlands