NCT02745522

Can Oxytocin Enhance the Placebo Effect?

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 224 (actual)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The current study aimed to investigate whether oxytocin (OXT) had effect on placebo effect.

Detailed description

The current study included three phases to investigate oxytocin effect on placebo effect: 1. In a double-blind, between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 66 healthy male subjects using working memory task. 2. In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 53 healthy male subjects using working memory task.They were informed that oxytocin would increase memory perfomance by a female experimenter. 3. In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 53 healthy male subjects using working memory task. But the subjects were told that oxytocin would decrease the performance by the same female experimenter. 4. In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 52 healthy male subjects using working memory task. The subjects were told that oxytocin would increase the performance by a male experimenter. Memory performance was included as dependant factor. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), Interpersonal Trust Scale(ITS).

Conditions

• Oxytocin Effect on Memory Performance During Phase 1
• Oxytocin Effect on Memory Performance During Phase 2
• Oxytocin Effect on Memory Performance During Phase 3
• Oxytocin Effect on Memory Performance During Phase 4

Interventions

Type	Name	Description
DRUG	Oxytocin
DRUG	Placebo

Timeline

• Start date: 2015-12-01
• Primary completion: 2017-03-01
• Completion: 2017-08-01
• First posted: 2016-04-20
• Last updated: 2018-10-15

Locations

1 site across 1 country: China