Trials / Completed
CompletedNCT02745444
Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- University of Cologne · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans. The protective effect of the low-calorie diet and also of the protein-restriction in donor on transplant qualities and functions in receptor will also be investigated. Analysis of transcriptome, lipidome, metabolome, epigenome, proteome und phosphoproteome through tissue samples as well as blood samples for comparison of low-calorie diet, protein-restriction and no-diet groups.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | low-calorie formula diet | |
| DIETARY_SUPPLEMENT | protein-restricted diet |
Timeline
- Start date
- 2015-04-01
- Primary completion
- 2019-05-17
- Completion
- 2020-05-01
- First posted
- 2016-04-20
- Last updated
- 2021-09-29
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT02745444. Inclusion in this directory is not an endorsement.