Trials / Completed
CompletedNCT02741960
The Effect of Metformin on Reducing Lupus Flares
A Multicenter, Randomised, Double-blind Placebo Controlled Trial on the Efficacy and Safety of add-on Metformin to Conventional Immunosuppressants in Systemic Lupus Erythematosus
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 180 (actual)
- Sponsor
- RenJi Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This is a multicenter, randomised, double-blind placebo controlled trial on the efficacy and safety of add-on metformin to conventional immunosuppressants in systemic lupus erythematosus (SLE). The purpose of this study is to evaluate: 1) the effect of metformin on reducing disease flares; 2) the influence of metformin on corticosteroid sparing effect; 3) the influence of metformin on body mass index (BMI); 4) the safety of metformin.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | metformin | 500 mg metformin three times daily |
| DRUG | placebo | 500 mg placebo three times daily |
Timeline
- Start date
- 2016-05-24
- Primary completion
- 2017-12-13
- Completion
- 2018-12-07
- First posted
- 2016-04-18
- Last updated
- 2019-09-17
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT02741960. Inclusion in this directory is not an endorsement.