NCT02741063

Oxytocin Effect on Attentional Bias Towards Emotional Expression Faces in Individuals With High and Low Autistic Traits: A Functional Magnetic Resonance Imaging (fMRI) Study

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

to investigate whether oxytocin alter attentional bias towards emotional expression faces in individuals with high and low autistic traits, and the brain mechanism of this effect

Detailed description

In the present study, investigator plan to use a double-blind, between-subject placebo controlled design.Firstly, all healthy male subjects' autistic trait levels will be assessed by the Autism Spectrum Quotient (ASQ) and only subjects with higher or lower ASQ score will be recruited in the next experiment and divided into high and low subgroup. Then, subjects are randomly assigned to receive either intranasal administration of oxytocin (24 IU) or placebo. 45 min later, subject need to complete an attentional bias task named rapid serial visual presentation (RSVP) task in fMRI scanner.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	screen low autistic subjects	screen subjects with low ASQ score
BEHAVIORAL	screen high autistic subjects	screen subjects with high ASQ score
DRUG	oxytocin	intranasal administration of oxytocin (24 IU)
DRUG	placebo	intranasal administration of placebo (24 IU)

Timeline

• Start date: 2016-05-01
• Primary completion: 2019-06-01
• Completion: 2019-09-01
• First posted: 2016-04-18
• Last updated: 2018-10-29

Locations

1 site across 1 country: China