NCT02739958

Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx

Effects of Propofol-dexmedetomidine on Immune Function During Total Laryngectomy Surgery Compared With Isoflurane Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The aim of this prospective, randomized clinical study is to compare between propofol and isoflurane on perioperative immune cell populations and function in patients undergoing total laryngectomy surgery.

Detailed description

The perioperative period might be a critical time in primary cancer surgery because many factors can affect whether recurrence, or metastasis , or elimination by the immune system. Cancer surgery can induce an acute inflammatory response, due to local tissue damage and the shedding of malignant cells into the blood and lymphocytic circulation although meticulous surgical manipulation. Many evidences suggest that several factors during the perioperative period can affect the immune system. These could be attributed to the surgery per se, pain, anxiety, hypothermia, blood transfusion, anesthetic technique, and anesthetic drugs .Impairment in the immune system may allow malignant cells to escape immuno-surveillance and metastasize in the perioperative period.As well as increase the risk of postoperative complications, such as systemic inflammatory response syndrome, sepsis, and multi-organ failure. Previous retrospective clinical studies of both breast and prostate cancer surgery have suggested an association between anaesthetic technique and cancer recurrence. However ,other retrospective trials on various forms of cancer have shown no such benefit.

Conditions

• Cancer Larynx
• Total Laryngectomy

Interventions

Type	Name	Description
DRUG	Propofol group	Anesthesia is maintained with continuous infusion of propofol 1.5-2mg/kg/h and dexmedetomidine 0.2-1ug/kg/h.
DRUG	Isoflurane group	Anesthesia was maintained with isoflurane at a concentration of 2-2.5%. fentanyl 50 ug increments

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-08-30
• Completion: 2016-10-30
• First posted: 2016-04-15
• Last updated: 2020-09-22

Locations

1 site across 1 country: Egypt