NCT02737800

Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients

Effect of Prolonged GnRh Agonist Therapy on the Outcome of In-Vitro Fertilization& Embryo Transfer in Endometrioma Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Kasr El Aini Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients

Detailed description

Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into: Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into : Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol

Conditions

• Endometrioma

Interventions

Type	Name	Description
PROCEDURE	endometrioma aspiration	Transvaginal ultrasound guided aspiration
DRUG	GnRh agonist ( Decapeptyl )	3 monthly doses of Decapeptyl 7.5mg intramuscular
PROCEDURE	standard long stimulation protocol	Decapeptyl 3.75mg in the mid luteal phase followed by human menopausal gonadotropins(HMG);fostimon, or merional injections after bleeding, doses are individualization according to each patient, monitored by follicular size \&serum estradiol.

Timeline

• Start date: 2016-04-01
• Primary completion: 2017-08-01
• Completion: 2017-08-01
• First posted: 2016-04-14
• Last updated: 2018-07-31

Locations

1 site across 1 country: Egypt