NCT02734953

Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH

Effects of iNO on Invasively Derived Pulmonary Vascular Parameters in Patients With Pulmonary Arterial Hypertension

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Pulmonary hypertension is characterized by an increase in the pressures in the blood supply to the lungs greater than a mean pressure of 25mmHg and a concomitant increase in overall pulmonary vascular resistance (PVR). In patients who have remodeling of their pulmonary vasculature, PVR will increase with exercise instead of decreasing as it would in normal patients. Based on published evidence, the investigators intend to investigate the effects of inhaled nitric oxide (iNO) on patients undergoing standard exercise techniques who have separately and previously had an implanted pulmonary artery monitoring device (CardioMems by St Jude Medical, Inc.) placed.

Conditions

• Pulmonary Arterial Hypertension

Interventions

Type	Name	Description
DRUG	Nitric Oxide	Ambulatory inhaled nitric oxide delivery system and 6 minute walk distance test

Timeline

• Start date: 2016-04-01
• Primary completion: 2016-08-01
• Completion: 2016-12-01
• First posted: 2016-04-12
• Last updated: 2018-09-24
• Results posted: 2018-09-24

Locations

1 site across 1 country: United States