NCT02733640

Does Pantoprazole Reduce the Anti-platelet Effect of Clopidogrel?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

The investigators sought to evaluate the influence of pantoprazole, indicated as less effective than other proton pump inhibitors, on the antiplatelet effect of clopidogrel, with stratification of the population according to the presence of cytochrome (CYP) 2C19 polymorphism.

Detailed description

Participants being treated with a maintenance dose of 75 mg clopidogrel and 100 mg aspirin daily after previous PCI with coronary stenting were included in the study. Participants were randomly assigned to either the pantoprazole 40 mg once-daily group or the ranitidine 150 mg twice-daily group using a computer-generated randomized table. An independent investigator generated the random allocation sequence. Blood samples were collected at 9:00 on day prior to treatment (day 0) and on day 9. Measuring impedance was performed by one independent investigator in a blinded manner.

Conditions

• Antiplatelet Effect

Interventions

Type	Name	Description
DRUG	Pantoprazole	pantoprazole 40 mg once-daily
DRUG	Ranitidine	ranitidine 150 mg twice-daily

Timeline

• Start date: 2012-10-01
• Primary completion: 2015-05-01
• Completion: 2015-05-01
• First posted: 2016-04-11
• Last updated: 2016-04-11

Locations

1 site across 1 country: South Korea