NCT02728440

Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism

Lipid Profile and Oxidative Stress Parameters of Patients With Idiopathic Hypogonadotropic Hypogonadism and the Change of These Parameters With Gonadotropin Replacement Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Gulhane School of Medicine · Academic / Other
• Sex: Male
• Age: 22 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

Detailed description

30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Conditions

• Idiopathic Hypogonadotropic Hypogonadism

Interventions

Type	Name	Description
DRUG	human chorionic gonadotropin, human menopausal gonadotropin	drug for the treatment of male hypogonadism

Timeline

• Start date: 2010-05-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2016-04-05
• Last updated: 2016-04-13