NCT02727504

Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 86 (actual)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 45 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve stenosis.

Conditions

• Aortic Valve Stenosis

Interventions

Type	Name	Description
DEVICE	Electrocardiogram	ECG at inclusion and M12
DEVICE	2D and 3D echocardiography	2D and 3D echocardiography at inclusion and M12
DEVICE	Dobutamine stress echocardiography	dobutamine stress echocardiography at inclusion
BIOLOGICAL	Blood tests	Blood test electrolytes, creatinine, hemoglobin, NT-proBNP, CRP, ST-2 at inclusion and M12
DEVICE	Cardiac MRI	Cardiac MRI at inclusion
DEVICE	Cardiac scanner	Cardiac scanner at inclusion
OTHER	6-minutes walking test	6-minutes walking test at inclusion and M12
OTHER	Duke Activity Score	Duke Activity Score at inclusion and M12

Timeline

• Start date: 2016-05-11
• Primary completion: 2020-01-06
• Completion: 2020-01-06
• First posted: 2016-04-04
• Last updated: 2020-02-07

Locations

1 site across 1 country: France