NCT02727166

Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function

Efecto de Fructanos Paralelamente Hidrolizados Provenientes de Achicoria Sobre Las Sensaciones Abdominales

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 67 (actual)
• Sponsor: Hospital Universitari Vall d'Hebron Research Institute · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Subjects with gas-related complaints exhibit impaired handling of intestinal gas loads and we hypothesized that inulin would have a beneficial effect. Aim: to determine the effect of a prebiotic chicory-derived inulin-type fructan on the tolerance of intestinal gas. Methods. Placebo-controlled, parallel, randomized and double-blind trial study. Subjects with abdominal symptoms and reduced tolerance of intestinal gas (selected by a pre-test) will receive either inulin (8 g/d, n=18) or maltodextrin as a placebo (8 g/d, n=18) for 4 wk. A gas challenge test (4 h jejunal gas infusion at 12 mL/min while measuring abdominal symptoms and gas retention for 3 h) will be performed before and at the end of the intervention phase. Gastrointestinal symptoms and bowel habits (using daily questionnaires for 1 wk) and fecal bifidobacteria counts will be measured before and at the end of the intervention.

Conditions

• Functional Gastrointestinal Disorders

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Inulin	Administered in 4 g sacchets taken in 200 mL liquid during breakfast and dinner for 4 week intervention period
DIETARY_SUPPLEMENT	Maltodextrine	Administered in 4 g sacchets taken in 200 mL liquid during breakfast and dinner for 4 week intervention period

Timeline

• Start date: 2010-11-01
• Primary completion: 2015-07-01
• Completion: 2015-12-01
• First posted: 2016-04-04
• Last updated: 2016-04-04