NCT02726308

Dexamethasone With Super-hydration for Prevention of Postoperative Nausea and Vomiting

Dexamethasone Alone Versus in Combination With Intra-operative Super-hydration for Prevention of Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Postoperative nausea and vomiting (PONV) are the most common and distressing side effects following Laparoscopic cholecystectomy

Detailed description

In the operating room, standard monitors included electrocardiogram, noninvasive arterial blood pressure, arterial oxygen saturation, and end-tidal carbon dioxide were connected. All patients received standardized anesthetic technique. At the end of surgery, gastric contents were suctioned via an orogastric tube before extubation. Atropine and neostigmine (1/2.5 mg) was given slowly I.V. to antagonize the residual neuromuscular block. Then, the trachea was extubated. Then, patients were transferred to the post-anesthesia care unit in a stable condition. Patients were allowed to drink liquids as soon as requested.

Conditions

• Nausea and Vomiting, Postoperative

Interventions

Type	Name	Description
DRUG	Dexamethasone	5 mg I.V. Dexamethasone just before induction
DRUG	10 ml/kg Ringer's lactate	Intra-operative 10 ml/kg Ringer's lactate solution .
DRUG	30 ml/kg Ringer's lactate	Intra-operative 30 ml/kg Ringer's lactate solution .

Timeline

• Start date: 2015-05-01
• Primary completion: 2016-03-01
• Completion: 2016-03-01
• First posted: 2016-04-01
• Last updated: 2016-04-01

Locations

1 site across 1 country: Egypt