NCT02725190

Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: Male
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.

Detailed description

Sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (SD) could impact respiratory muscle endurance. A lack of inspiratory endurance could lengthen weaning from invasive ventilation. The purpose of this study is to confirm whether SD alters inspiratory endurance and to identify brain mechanisms involved in SD-induced decreased endurance. A group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. Electrophysiological parameters (EEG, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Conditions

• Sleep Deprivation
• Healthy Volunteers
• Diaphragm

Interventions

Type	Name	Description
BEHAVIORAL	Sleepless night	Each subject will undergo 28 hours of sleep deprivation.
BEHAVIORAL	Normal sleep night	Normal sleep at home before trial.

Timeline

• Start date: 2016-04-01
• Primary completion: 2017-08-01
• Completion: 2017-12-01
• First posted: 2016-03-31
• Last updated: 2017-12-11

Locations

1 site across 1 country: France