NCT02717273

Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics

A Randomized, Prospective Study of Surgical Site Infections in Liver Transplant Patients Receiving Three Days of Peri-operative Antibiotic Prophylaxis Versus Intra-operative Antibiotics Only

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.

Detailed description

This study will be to prospectively determine differences in SSI if a prolonged course of post-operative antibiotics are used following liver transplantation. All adult patients, admitted to the University of Virginia (UVA) Medical Center for first-time liver transplantation will be randomized to the standard of care of peri-operative antibiotics or extended course of three total days. Patients will be evaluated primarily for the presence of post-operative surgical site infections but also for fever, elevated white blood counts, secondary infections (urinary tract, pneumonia, and blood stream), length of hospital stay, graft loss, and mortality for 30 days after liver transplant.

Conditions

• Liver Transplantation
• Surgical Site Infection

Interventions

Type	Name	Description
DRUG	standard	peri-operative antibiotic regimen only
DRUG	extended	extended three-day course of antibiotics
OTHER	liver transplant	orthotopic liver transplantation

Timeline

• Start date: 2009-03-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2016-03-23
• Last updated: 2018-07-17
• Results posted: 2018-07-17