NCT02717013

The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Metabolic Technologies Inc. · Industry
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will determine the effects of supplementing beta-hydroxy-beta-methylbutyrate (HMB) on body composition and strength changes during weight loss. When overweight and obese persons lose weight, and in particular in conjunction with dietary restrictions, muscle, bone mass, and muscle strength are also lost. HMB has been shown to preserve muscle mass and strength, and it is thought that HMB may also preserve muscle, bone, and strength during weight-loss.

Detailed description

Forty obese men (BMI 35-40 kg/m2,18-40 years of age) will be randomly assigned to one of four treatment interventions: 1) Calorie restricted; 2) Calorie restricted and HMB supplemented; 3) No calorie restriction; and 4) No calorie restriction and HMB-supplemented. Over the 8 week interventional period the calorie restricted group is expected to lose 3-5% of initial body weight. Anthropometric measures will be taken weekly, and dual energy x-ray absorptiometry (DXA) body composition and strength will be measured before and after 8-weeks of intervention. Blood and urine will be collected and analyzed at 0, 4, and 8 weeks. Additionally Dietary records and questionnaires concerning quality of life will be administered, and activity will be assessed using questionnaires and pedometers. Muscle biopsies will be taken before and after the 8-week study.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Placebo capsules containing calcium lactate similar to the HMB capsules.
DIETARY_SUPPLEMENT	HMB	HMB capsules supplying 3 grams per day of calcium beta-hydroxyl-beta-methylbutyrate.

Timeline

• Start date: 2016-03-01
• Primary completion: 2017-02-01
• Completion: 2017-02-01
• First posted: 2016-03-23
• Last updated: 2017-03-03

Locations

1 site across 1 country: United States