NCT02715869

Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be (ischemic ; pharmacologic or Physical).

Detailed description

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ; pharmacologic or Physical) Pharmacological PC may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc) Ischemic PC includes local; remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs. The liberated mediators have favorable effects not only upon the myocardium, but it extend to protect other organs against inflammatory activation; ischemia reperfusion injury Inotropic score (IS) is already an evident predictor of postoperative cardiac morbidity and mortality Aim of the work: Is to validate the impact of Sevoflurane versus ischemic \& Sevoflurane PC upon postoperative inotropic score in adult patient undergoing open heart surgery

Conditions

• Myocardial Ischemia

Interventions

Type	Name	Description
DRUG	A pharmacologic cardiac preconditioning (Sevoflurane)	A Patients are anaesthetized by Sevoflurane more than 1 mac.
PROCEDURE	B ischeamic preconditioning	B ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Timeline

• Start date: 2016-03-01
• Primary completion: 2017-03-01
• Completion: 2017-06-01
• First posted: 2016-03-22
• Last updated: 2017-12-12

Locations

1 site across 1 country: Egypt